PERFECTO stands for “Preventing the Preventable – Familial Hypercholesterolaemia Paediatric Screening for Cardiovascular Health.” This project is focused on childhood screening programs for inherited high cholesterol, which runs in families. These programs help detect this serious cardiovascular disease (CVD) risk factor early, which can prevent premature heart attacks and other serious health complications. By implementing simple healthy living habits such as a healthy, low-fat diet, physical activity, and avoiding smoking, FH can be managed day-to-day alongside medication, promoting overall cardiovascular health (CVH).

Familial hypercholesterolaemia (FH) is the most common genetic cardiovascular risk factor globally. Because it is inherited, it is passed on within families. It is estimated that one in 300 people has inherited high cholesterol, which translates to two million adults and five hundred thousand children being affected in Europe alone. If FH is diagnosed and managed early in childhood, individuals can have a normal life expectancy. However, the identification of FH is very low, with nine out of ten people remaining undetected. This means that approximately 90% of individuals with FH are still undiagnosed, living with a significant risk of developing premature cardiovascular disease.